Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Wheels within wheels: theory and practice of epileptic networks
The concept of an epileptic network is based on the longstanding clinical observation that
ictal electroencephalography (EEG) patterns cannot be easily explained by the traditional …
ictal electroencephalography (EEG) patterns cannot be easily explained by the traditional …
Neural fragility as an EEG marker of the seizure onset zone
Over 15 million patients with epilepsy worldwide do not respond to drugs. Successful
surgical treatment requires complete removal or disconnection of the seizure onset zone …
surgical treatment requires complete removal or disconnection of the seizure onset zone …
Source-sink connectivity: A novel interictal EEG marker for seizure localization
Over 15 million epilepsy patients worldwide have drug-resistant epilepsy. Successful
surgery is a standard of care treatment but can only be achieved through complete resection …
surgery is a standard of care treatment but can only be achieved through complete resection …
Passive and active markers of cortical excitability in epilepsy
Electroencephalography (EEG) has been the primary diagnostic tool in clinical epilepsy for
nearly a century. Its review is performed using qualitative clinical methods that have …
nearly a century. Its review is performed using qualitative clinical methods that have …
Control theory illustrates the energy efficiency in the dynamic reconfiguration of functional connectivity
The brain's functional connectivity fluctuates over time instead of remaining steady in a
stationary mode even during the resting state. This fluctuation establishes the dynamical …
stationary mode even during the resting state. This fluctuation establishes the dynamical …
Connectivity within regions characterizes epilepsy duration and treatment outcome
X Chen, Y Wang, SJ Kopetzky… - Human Brain …, 2021 - Wiley Online Library
Finding clear connectome biomarkers for temporal lobe epilepsy (TLE) patients, in particular
at early disease stages, remains a challenge. Currently, the whole‐brain structural …
at early disease stages, remains a challenge. Currently, the whole‐brain structural …
Controllability analysis of functional brain networks
Network control theory has recently emerged as a promising approach for understanding
brain function and dynamics. By operationalizing notions of control theory for brain networks …
brain function and dynamics. By operationalizing notions of control theory for brain networks …
Neural fragility of the intracranial EEG network decreases after surgical resection of the epileptogenic zone
Over 15 million patients with epilepsy worldwide do not respond to medical therapy and may
benefit from surgical treatment. In cases of focal epilepsy, surgical treatment requires …
benefit from surgical treatment. In cases of focal epilepsy, surgical treatment requires …
[PDF][PDF] Source-sink connectivity: A novel resting-state EEG marker of the epileptogenic zone.
Over 15 million epilepsy patients worldwide have medically refractory epilepsy (MRE), ie,
they do not respond to anti-epileptic drugs. Successful surgery is a hopeful alternative for …
they do not respond to anti-epileptic drugs. Successful surgery is a hopeful alternative for …