Kléber, André G., and Yoram Rudy. Basic Mechanisms of Cardiac Impulse Propagation and
Associated Arrhythmias. Physiol Rev 84: 431–488, 2004; 10.1152/physrev. 00025.2003 …

In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Optical techniques have revolutionized the investigation of cardiac cellular physiology and
advanced our understanding of basic mechanisms of electrical activity, calcium …

The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

A" brain defibrillator" may be closer than we think. An epileptic seizure involves a
paroxysmal change in the activity of millions of neurons. Feedback control of seizures would …

▪ Abstract Electric fields can stimulate excitable tissue by a number of mechanisms. A
uniform long, straight peripheral axon is activated by the gradient of the electric field that is …

Highlights•Postinfarction ventricular tachycardia (VT) caused by a reentrant circuit is an
important clinical problem.•Catheter ablation may not prevent VT because of difficulty in …

Whether hypercholesterolemia (HC) can induce proarrhythmic neural and
electrophysiological remodeling is unclear. We fed rabbits with either high cholesterol (HC …

Anisotropy, the property of being directionally dependent, is ubiquitous in nature.
Propagation of the electrical impulse in cardiac tissue is anisotropic, a property that is …

Phase Singularity Dynamics. Introduction: Quantitative analysis of complex self‐excitatory
wave patterns, such as cardiac fibrillation and other high‐order reentry, requires the …