Although the complement system is primarily perceived as a host defence system, a more
versatile, yet potentially more harmful side of this innate immune pathway as an …

Habitually professional phagocytes, including macrophages, eradicate microbial invaders
from the human body without overt signs of infection. Despite this, there exist select bacteria …

PTX3 is an essential component of the humoral arm of innate immunity, playing a
nonredundant role in resistance against selected microbes and in the regulation of …

The innate immune system comprises a cellular and a humoral arm. Humoral pattern
recognition molecules include complement components, collectins, ficolins, and pentraxins …

Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …

Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in
evolution and characterized by a cyclic multimeric structure. C-reactive protein (CRP) and …

Primary IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and kidney
failure for which there is no disease-specific treatment. However, this could change, since …

Abstract The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was
formed to evaluate the effectiveness of long-read approaches for transcriptome analysis …

Humoral fluid phase pattern recognition molecules (PRM s) are a key component of the
activation and regulation of innate immunity. Humoral PRM s are diverse. We focused on the …

Elements of the immune system particularly that of innate immunity, play important roles
beyond their traditional tasks in host defense, including manifold roles in the nervous …