Abstract Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …

The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Despite its very low level in humans, selenium plays an important and unique role among
the (semi) metal trace essential elements because it is the only one for which incorporation …

Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus,
known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally …

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

This review covers current knowledge of selenium in the environment, dietary intakes,
metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant …

Mitochondria serves a primary role in energy maintenance but also function to govern levels
of mitochondria-derived reactive oxygen species (mROS). ROS have long been established …

The essential trace element, selenium (Se), has multiple biological activities, which depend
on the level of Se intake. Relatively low Se intakes determine the expression of …

Simple Summary Glutathione peroxidase 1 (GPX1), as one of the most important antioxidant
enzymes, maintains cellular redox balance by regulating reactive oxygen species levels. In …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …