Abstract Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive
signaling. In addition to playing critical roles in cellular heat shock response, emerging …

Cell death is a common and active process that is involved in various biological processes,
including organ development, morphogenesis, maintaining tissue homeostasis and …

Emerging evidence revealed the significant roles of heat shock factor 1 (HSF1) in cancer
initiation, development, and progression, but there is no pan‐cancer analysis of HSF1. The …

Acute myeloid leukemia (AML) is maintained by self-renewing leukemic stem cells (LSCs). A
fundamental problem in treating AML is that conventional therapy fails to eliminate LSCs …

RNA sequencing (RNA-seq) has become a routine method for transcriptomic profiling. We
developed a user-friendly web app called iDEP (integrated differential expression and …

Cells employ a well-preserved physiological stress response mechanism, termed the heat
shock response, to activate a certain type of molecular chaperone called heat shock proteins …

kDa Heat Shock Proteins (HSPA/HSP70) are chaperones playing a central role in the
proteostasis control mechanisms. Their basal expression can be highly elevated as an …

Simple Summary Acquired resistance to chemoradiotherapy is the common cause of
relapse in cancer treatments. Although chemoradiotherapy often produces promising results …

Super-enhancer (SE) plays a vital role in the determination of cell identity and fate. Up-
regulated expression of coding genes is frequently associated with SE. However, the …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most
common cause of dementia in older people. AD is associated with the loss of synapses …