Background As reported, preclinical animal models differ greatly from the human body. The
evaluation model may be the colossal obstacle for scientific research and anticancer drug …

Cancer is a severe threat to human life and health and represents the main cause of death
globally. Drug therapy is one of the primary means of treating cancer; however, most …

Abstract CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type
of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the …

Abstract Capicua-double homeobox 4 (CIC-DUX4)–rearranged sarcomas (CDS) are
extremely rare, highly aggressive primary sarcomas that represent a major therapeutic …

Simple Summary In this review, we aim to summarize the current clinical and biological
knowledge for patients affected by a rare soft-tissue sarcoma, the CIC-rearranged sarcoma …

Synovial sarcoma is an aggressive malignancy with no effective treatments for patients with
metastasis. The synovial sarcoma fusion SS18-SSX, which recruits the SWI/SNF-BAF …

Capicua (CIC)-rearranged sarcomas are an aggressive subset of undifferentiated round cell
sarcomas. CIC:: DUX4, the proto-typical CIC fusion oncoprotein is associated with rapid …

CIC-DUX4 rearrangements define an aggressive and chemotherapy-insensitive subset of
undifferentiated sarcomas. The CIC-DUX4 fusion drives oncogenesis through direct …

Simple Summary CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue
tumor predominantly affecting young adults for which the only oncogenic driver is the CIC …

(1) Background: CIC-DUX4 sarcoma is a rare mesenchymal small round cell tumor which
belongs to rare cancers that occupy a significant percentage of cancer cases as a whole …