Native tissues, comprising multiple cell types and extracellular matrix components, are
inherently composites. Mimicking the intricate structure, functionality, and dynamic …

Tibial fractures represent a great burden of disease globally, being the most common long-
bone fracture; smoking is a known risk factor for delayed skeletal healing and post-fracture …

The study investigated whether both the osteogenic and angiogenic potential of Exos
(Exosomes) can be enhanced by overexpression of exosomal miRNA (microRNA) and to …

Purpose To investigate the effect of macrophage exosomal long non-coding (lnc) RNAs on
bone mesenchymal stem cell (BMSC) osteogenesis and the associated mechanism …

Background and Objectives: Fracture healing is currently assessed through qualitative
evaluation of radiographic images, which is highly subjective in nature. Radiographs can …

Bone tissue engineering (BTE) is an ongoing field of research based on clinical needs to
treat delayed and non-union long bone fractures. An ideal tissue engineering scaffold …

Nonunions and delayed unions pose significant challenges in orthopedic treatment, with
current therapies often proving inadequate. Bone tissue engineering (BTE), particularly …

Nonunion is a complication of long bone fractures that leads to disability, morbidity and high
costs. Early detection is difficult and treatment through external stimulation and revision …

The treatment of bone defects is still an intractable clinical problem, despite the fact that
numerous treatments are currently available. In recent decades, bone engineering scaffolds …

In the burgeoning domain of orthopedic therapeutic research, Platelet-Rich Plasma (PRP)
has firmly established its position, transforming paradigms ranging from tissue regeneration …