Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Micronuclei are small membrane-bounded compartments with a DNA content encapsulated
by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have …

The aetiology of inflammatory bowel disease (IBD) is a multifactorial interplay between
heredity and environment,. Here we report that deficiency in SETDB1, a histone …

The porosity and stability of chiral metal-organic frameworks (CMOFs) are crucial for
enantioselective applications. However, coupling these properties by directly assembling …

Biological sex is a factor in many conditions, including aging, neurodegenerative disease,
cancer, and more. For each of these, men and women display distinct differences in disease …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

RNA: DNA hybrids form when nascent transcripts anneal to the DNA template strand or any
homologous DNA region. Co-transcriptional RNA: DNA hybrids, organized in R-loop …

Biological sex profoundly conditions organismal development and physiology, imposing
wide-ranging effects on cell signaling, metabolism, and immune response. These effects …

DNA damage is a key factor affecting gametogenesis and embryo development. The
integrity and stability of DNA are fundamental to a woman's successful conception …

Meiotic crossovers are required for accurate chromosome segregation and producing new
allelic combinations. Meiotic crossover numbers are tightly regulated within a narrow range …