Lysosomal storage diseases (LSDs) are a group of over 70 diseases that are characterized
by lysosomal dysfunction, most of which are inherited as autosomal recessive traits. These …

Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …

In Alzheimer's disease (AD), abnormal sphingolipid metabolism has been reported,
although the pathogenic consequences of these changes have not been fully characterized …

Disrupted cellular Ca2+ signaling is believed to play a role in a number of human diseases
including lysosomal storage diseases (LSD). LSDs are a group of∼ 50 diseases caused …

Calcium (Ca2+) signaling is an essential process in all cells that is maintained by a plethora
of channels, pumps, transporters, receptors, and intracellular Ca2+ sequestering stores …

Neuropathic lysosomal storage disorders (LSD s) present with activated pro‐inflammatory
microglia. However, anti‐inflammatory treatment failed to improve disease pathology. We …

Alzheimer's disease (AD) is the most common progressive neurodegenerative disease
worldwide, but its cause remains unclear. Although a few drugs can provide temporary and …

Microglia have the ability to eliminate amyloid β (Aβ) by a cell-specific phagocytic
mechanism, and bone marrow (BM) stem cells have shown a beneficial effect through …

Ataxic mutant mice can be used to represent models of cerebellar degenerative disorders.
They serve for investigation of cerebellar function, pathogenesis of degenerative processes …

The cerebellum is endowed with the capacity for compensation and restoration after
pathological injury, a property known as cerebellar reserve. Such capacity is attributed to …