Immune cells of the myeloid and lymphoid lineages express Toll-like receptors (TLRs) to
recognize pathogenic components or cellular debris and activate the immune system …

Immune recognition of virus-associated molecules by Toll-like receptors (TLRs) and/or RIG-I-
like receptors (RLRs) triggers intracellular signaling cascades that converge on the …

Summary Type I Interferons (IFNs) are important cytokines for innate immunity against
viruses and cancer. Sixteen human type I IFN variants signal through the same cell-surface …

Type I interferons (IFNs) activate differential cellular responses through a shared cell surface
receptor composed of the two subunits, IFNAR1 and IFNAR2. We propose here a …

Achieving therapeutic efficacy in protein replacement therapies requires sustaining
pharmacokinetic (PK) profiles, while maintaining the bioactivity of circulating proteins. This is …

Site-selective conjugation generally requires both (i) molecular engineering of the protein of
interest to introduce a conjugation site at a defined location and (ii) a site-specific …

The human interferon α2 (IFNα2) was the first highly active IFN subtype to be cloned in the
early eighties. It was also the first IFN and the first cytokine to be produced and …

Protein, nucleic acid, and small-molecule drugs frequently require chemical modification
with polymers such as polyethylene glycol (PEG), to increase their in vivo circulation time …

Type I interferons (IFNs) are multifunctional cytokines that activate cellular responses by
binding a common receptor consisting of two subunits, IFNAR-1 and IFNAR-2. Although the …

The field of the present invention relates to genetically engi neered fusion molecules,
methods of making said fusion mol ecules, and uses thereof in anti-tumor immunotherapies …