Uterine sarcomas are very infrequent and heterogeneous entities. Due to its rarity,
pathological diagnosis, surgical management, and systemic treatment are challenging …

Mesenchymal spindle cell tumors with kinase fusions, often presenting in superficial or deep
soft tissue locations, may rarely occur in bone. Herein, we describe the clinicopathologic and …

Simple Summary Gene fusions produce chimeric fusion proteins with unpredictable
properties, many of which function as oncogenic drivers. ETV6-NTRK3 produces a …

Context.—The neurotrophic tropomyosin receptor kinase (NTRK) family gene
rearrangements have been recently incorporated as predictive biomarkers in a “tumor …

Alterations in kinase genes such as NTRK1/2/3, RET, and BRAF underlie infantile
fibrosarcoma (IFS), the emerging entity 'NTRK‐rearranged spindle cell neoplasms' included …

The landscape of uterine sarcomas is becoming increasingly complex with the description of
new entities associated with recurrent molecular alterations. Uterine sarcomas, as well as …

NTRK-rearranged spindle cell neoplasm represents an emerging entity included in the latest
5th edition of WHO classification of both soft tissue and female genital tumors. By …

Uterine mesenchymal neoplasms are a challenging group of tumors that often show
overlapping morphologic features and immunohistochemical profiles. The increasing use of …

Context.—Non–smooth muscle uterine sarcomas are mostly represented by low-grade
endometrial stromal sarcoma. However, several other rare, distinct types of uterine sarcoma …

Ovarian cancer is the second most common cause of gynecologic cancer death.
Chemoresistance and metastasis remain major challenges for current treatment. Previously …