Context.—Chordomas are uncommon malignant neoplasms with notochordal differentiation
encountered by neuropathologists, bone/soft tissue pathologists, and general surgical …

Objectives: Chordoma is a rare bone malignancy that affects the spine and skull base.
Treatment dilemma leads to a high rate of local relapse and distant metastases. Molecular …

A classically identified “notochordal” cell population in the nucleus pulposus is thought to
regulate disk homeostasis. However, the embryonic origin of these cells has been under …

BACKGROUND Chordomas are rare bone tumors arising from remnants of the embryonic
notochord. METHODS Data for this study were obtained from the Surveillance …

Retroperitoneal tumors are extremely rare. More than 70% of primary retroperitoneal soft
tissue tumors are malignant. The most common sarcomas in the retroperitoneum include …

Over the past decade, there have been numerous advances in our understanding of the
molecular pathogenesis of tuberous sclerosis complex (TSC). Following the identification of …

Brain plasticity is the potential of the nervous system to reshape itself during ontogeny,
learning or following injuries. The first part of this article reviews the pathophysiological …

PURPOSE: The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase
is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto …

Chordomas are radio-and chemo-resistant tumours and metastasise in as many as 40% of
patients. The aim of this study was to identify potential molecular targets for the treatment of …

The molecular events in chordoma pathogenesis have not been fully delineated, particularly
with respect to copy number changes. Understanding copy number alterations in chordoma …