Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape

NI Mazur, J Terstappen, R Baral, A Bardají… - The Lancet Infectious …, 2023 - thelancet.com
Respiratory syncytial virus is the second most common cause of infant mortality and a major
cause of morbidity and mortality in older adults (aged> 60 years). Efforts to develop a …

Respiratory syncytial virus vaccines: a review of the candidates and the approved vaccines

X Topalidou, AM Kalergis, G Papazisis - Pathogens, 2023 - mdpi.com
Respiratory syncytial virus (RSV) is responsible for a significant proportion of global
morbidity and mortality affecting young children and older adults. In the aftermath of formalin …

Epidemiology of respiratory syncytial virus in children younger than 5 years in England during the COVID-19 pandemic, measured by laboratory, clinical, and …

M Bardsley, RA Morbey, HE Hughes… - The Lancet Infectious …, 2023 - thelancet.com
Background Seasonal epidemics of respiratory syncytial virus (RSV) cause a clinically
significant burden of disease among young children. Non-pharmaceutical interventions …

Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study …

D Wilkins, AC Langedijk, RJ Lebbink… - The Lancet Infectious …, 2023 - thelancet.com
Background Nirsevimab is an extended half-life monoclonal antibody to the respiratory
syncytial virus (RSV) fusion protein that has been developed to protect infants for an entire …

Global burden of lower respiratory infections during the last three decades

S Safiri, A Mahmoodpoor, AA Kolahi… - Frontiers in Public …, 2023 - frontiersin.org
Background Lower respiratory infections (LRIs) cause a substantial mortality, morbidity and
economic burden. The present study reported the global, regional and national burden of …

Economic burden and health-related quality-of-life among infants with respiratory syncytial virus infection: A multi-country prospective cohort study in Europe

Z Mao, X Li, A Dacosta-Urbieta, MN Billard… - Vaccine, 2023 - Elsevier
Background Respiratory syncytial virus (RSV) causes a considerable disease burden in
young children globally, but reliable estimates of RSV-related costs and health-related …

Cost of respiratory syncytial virus infections in US infants: systematic literature review and analysis

DM Bowser, KR Rowlands, D Hariharan… - The Journal of …, 2022 - academic.oup.com
Background Limited data are available on the economic costs of respiratory syncytial virus
(RSV) infections among infants and young children in the United States. Methods We …

Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a …

X Wang, Y Li, T Shi, LJ Bont, HY Chu, HJ Zar… - The Lancet, 2024 - thelancet.com
Background Infants and young children born prematurely are at high risk of severe acute
lower respiratory infection (ALRI) caused by respiratory syncytial virus (RSV). In this study …

The full value of immunisation against respiratory syncytial virus for infants younger than 1 year: effects beyond prevention of acute respiratory illness

DR Feikin, RA Karron, SK Saha, E Sparrow… - The Lancet Infectious …, 2024 - thelancet.com
Respiratory syncytial virus (RSV) is a leading cause of severe respiratory illness and death
among children worldwide, particularly in children younger than 6 months and in low …

Cost of childhood RSV management and cost-effectiveness of RSV interventions: a systematic review from a low-and middle-income country perspective

R Wittenauer, C Pecenka, R Baral - BMC medicine, 2023 - Springer
Background Approximately 97% of global deaths due to RSV occur in low-and middle-
income countries (LMICs). Until recently, the only licensed preventive intervention has been …