tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …

Although various functions of RNA are carried out in conjunction with proteins, some
catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little …

Ribonuclease (RNase) P is the universal ribozyme responsible for 5′-end tRNA
processing. We report the crystal structure of the Thermotoga maritima RNase P …

RNA motifs can be defined broadly as recurrent structural elements containing multiple
intramolecular RNA–RNA interactions, as observed in atomic-resolution RNA structures …

Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of
only two known RNA-based enzymes found in all three domains of life. The RNA component …

Genome-wide measurements of RNA structure can be obtained using reagents that react
with unpaired bases, leading to adducts that can be identified by mutational profiling on next …

The discovery of RNA-catalyzed phosphodiester bond cleavage by Cech and Altman in
1982− 1983 shattered the paradigm of protein-dependent biological catalysis and opened …

Abstract Ribonuclease P (RNase P) is a ubiquitous endonuclease that catalyses the
maturation of the 5′ end of transfer RNA (tRNA). Although it carries out a biochemically …

Ribonuclease P (RNase P) is an endonuclease involved in processing tRNA. It contains
both RNA and protein subunits and occurs in all three domains of life: namely, Archaea …

Ribonuclease (RNase) P is a ubiquitous ribozyme that cleaves the 5′ leader from
precursor tRNAs. Here, we report cryo-electron microscopy structures of the human nuclear …