The therapy of chronic inflammatory diseases like rheumatoid arthritis (RA) and
inflammatory bowel disease (IBD) has recently been enriched by the successful launch of …

The Aurora A kinase belongs to serine/threonine group of kinases, well known for its role in
cell cycle, especially in the regulation of mitosis. Numerous substrates of Aurora A kinase …

The majority of kinase inhibitors that have been developed so far—known as type I inhibitors—
target the ATP binding site of the kinase in its active conformation, in which the activation …

The ability of molecular docking, using the program Glide and an MM-GBSA postdocking
scoring protocol, to correctly rank a number of congeneric kinase inhibitors was assessed …

Kinase inhibitors that bind to the ATP cleft can be broadly classified into two groups: those
that bind exclusively to the ATP site with the kinase assuming a conformation otherwise …

Automated continuous flow systems coupled with online analysis and feedback have been
previously demonstrated to model and optimize chemical syntheses with little a priori …

Abnormal vascular smooth muscle cell (VSMC) proliferation has an important role in the
pathogenesis of both atherosclerosis restenosis and hypertension. Vascular endothelial …

Background: Protein kinases are essential enzymes propagating cellular signal transduction
processes and consequently emerged as central targets for drug discovery against a wide …

Using a simple technique to prepare many uracil derivatives as Schiff base of uracil 4, bis 6-
amino [5-(1-(4-aryl) ethylidene) amino)] pyrimidine-2, 4-dione 5–12 by heating of 5, 6 …

The cancer drug, Imatinib, is a selective Abl kinase inhibitor that does not inhibit the closely
related kinase c-Src. This one drug and its ability to selectively inhibit Abl over c-Src has …