Central nervous system demyelinating diseases: glial cells at the hub of pathology

VG Coutinho Costa, SES Araújo… - Frontiers in …, 2023 - frontiersin.org
Inflammatory demyelinating diseases (IDDs) are among the main causes of inflammatory
and neurodegenerative injury of the central nervous system (CNS) in young adult patients …

Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration

S Kardam, RK Ambasta, P Kumar - Ageing Research Reviews, 2024 - Elsevier
Neurodegenerative diseases (NDDs) are identified by the progressive deterioration of
neurons and a subsequent decline in cognitive function, creating an enormous burden on …

Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells

B Zong, F Yu, X Zhang, W Zhao, S Li, L Li - Frontiers in immunology, 2023 - frontiersin.org
Multiple sclerosis (MS) is a prevalent neuroimmunological illness that leads to neurological
disability in young adults. Although the etiology of MS is heterogeneous, it is well …

[HTML][HTML] Sex-dependent factors of alcohol and neuroimmune mechanisms

B Cruz, V Borgonetti, M Bajo, M Roberto - Neurobiology of Stress, 2023 - Elsevier
Excessive alcohol use disrupts neuroimmune signaling across various cell types, including
neurons, microglia, and astrocytes. The present review focuses on recent, albeit limited …

Microglial Reactivity Correlates with Presynaptic Loss Independent of β‐Amyloid and Tau

G Lan, X Chen, J Yang, P Sun, Y Cai, A Li… - Annals of …, 2024 - Wiley Online Library
Objective Triggering receptor expressed on myeloid cells‐2 (TREM2) and progranulin
(PGRN) are critical regulators of microglia activation and can be detected in cerebrospinal …

Aphanizomenon flos-aquae (AFA) Extract Prevents Neurodegeneration in the HFD Mouse Model by Modulating Astrocytes and Microglia Activation

G Galizzi, I Deidda, A Amato, P Calvi, S Terzo… - International Journal of …, 2023 - mdpi.com
Obesity and related metabolic dysfunctions are associated with neurodegenerative
diseases, such as Alzheimer's disease. Aphanizomenon flos-aquae (AFA) is a …

[HTML][HTML] Establishing normal serum values of neurofilament light chains and glial fibrillary acidic protein considering the effects of age and other demographic factors …

A Rodero-Romero, E Monreal, R Sainz-Amo… - International Journal of …, 2024 - mdpi.com
Multiple studies have shown the importance of blood-based biomarkers indicating axonal
damage (serum neurofilament light chains [sNfL]) or astroglia activation (serum glial fibrillary …

Diagnostic utility of cerebrospinal fluid biomarkers in patients with rapidly progressive dementia

LA Kuchenbecker, PW Tipton, Y Martens… - Annals of …, 2024 - Wiley Online Library
Objective This study was undertaken to apply established and emerging cerebrospinal fluid
(CSF) biomarkers to improve diagnostic accuracy in patients with rapidly progressive …

Exploring the management approaches of cytokines including viral infection and neuroinflammation for neurological disorders

MM Rahman, SA Mim, MAA Tumpa, MT Sarker… - Cytokine, 2022 - Elsevier
Considerable evidence supports that cytokines are important mediators of pathophysiologic
processes within the central nervous system (CNS). Numerous studies have documented …

Soluble TREM2 is a potential biomarker for the severity of primary angiitis of the CNS

T Guo, J Ma, J Sun, W Xu, H Cong, Y Wei… - Frontiers in …, 2022 - frontiersin.org
Background Primary angiitis of the central nervous system (PACNS) is a severe
inflammatory disease, and soluble triggering receptor expressed on myeloid cells 2 …