Structural and functional roles of 2'-O-ribose methylations and their enzymatic machinery across multiple classes of RNAs

S Höfler, T Carlomagno - Current Opinion in Structural Biology, 2020 - Elsevier
Highlights•Differential levels of 2'-O-methylation in rRNA might contribute to ribosome
specialization in different cell types.•rRNA methylation levels are controlled by regRNPs and …

Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization

MR Chao, YJ Chang, MS Cooke, CW Hu - TrAC Trends in Analytical …, 2024 - Elsevier
Adductomics, an emerging field within the'omics sciences, focuses on the formation and
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …

Exploring Glycosylated Soy Isoflavones Affinities toward G‐tetrads as Studied by Survival Yield Method

O Stężycka, M Frańska… - …, 2023 - Wiley Online Library
Taking soy‐based food supplements for menopausal symptoms by women may reduce the
risk of cancer. Therefore, the interaction between nucleic acids (or their constituents) and …

Structural determination of arginine-linked cisplatin complexes via IRMPD action spectroscopy: arginine binds to platinum via NO− binding mode

CC He, LA Hamlow, B Kimutai, HA Roy… - Physical Chemistry …, 2021 - pubs.rsc.org
Cisplatin,(NH3) 2PtCl2, has been known as a successful metal-based anticancer drug for
more than half a century. Its analogue, Argplatin, arginine-linked cisplatin,(Arg) PtCl2, is …

Influence of 5-fluorination on the structure and glycosidic bond stability of the protonated canonical DNA and RNA cytidine nucleosides: Oh, what a difference the 2 …

ZJ Devereaux, EO Soley, G Berden, J Oomens… - International Journal of …, 2024 - Elsevier
Fluorinated nucleosides are well-established as anticancer and antiviral medications. As
with many pharmaceuticals, the effects of fluorine modifications are often only partially …

Protonation-induced tautomerization lowers the activation barriers for N-glycosidic bond cleavage of thymidine and 5-methyluridine

RR Wu, MT Rodgers - International Journal of Mass Spectrometry, 2025 - Elsevier
Synergistic infrared multiple photon dissociation (IRMPD) action spectroscopy experiments
and electronic structure calculations revealed that both 2, 4-dihydroxy tautomers and O2 …

5-Halogenation of Uridine Suppresses Protonation-Induced Tautomerization and Enhances Glycosidic Bond Stability of Protonated Uridine: Investigations via IRMPD …

NN Mikawy, HA Roy, E Israel, LA Hamlow… - Journal of the …, 2022 - ACS Publications
Uridine (Urd), a canonical nucleoside of RNA, is the most commonly modified nucleoside
among those that occur naturally. Uridine has also been an important target for the …

Influence of 5-Halogenation on the Base-Pairing Energies of Protonated Cytidine Nucleoside Analogue Base Pairs: Implications for the Stabilities of Synthetic i-Motif …

MT Rodgers, YS Seidu, E Israel - … of the American Society for Mass …, 2022 - ACS Publications
DNA nanotechnology has been employed to develop devices based on i-motif structures.
The protonated cytosine-cytosine base pairs that stabilize i-motif conformations are favored …

Identification of 2'-O-methylation site by investigating multi-feature extracting techniques

QL Huang, L Wang, SG Han… - … Chemistry & High …, 2020 - ingentaconnect.com
Background: RNA methylation is a reversible post-transcriptional modification involving
numerous biological processes. Ribose 2'-O-methylation is part of RNA methylation. It has …

Characterization of Protonated Modified Nucleosides and Amino Acid-Linked Cisplatin Analogues Using Tandem Mass Spectrometry Complemented By Theoretical …

C He - 2018 - search.proquest.com
The chemical difference between DNA and RNA nucleosides is their 2'-hydrogen versus 2'-
hydroxyl substituents. The 2'-O-methylation is common among natural posttranscriptional …