Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Assessing the association between DNA variants and disease has been used widely to
identify regions of the genome and candidate genes that contribute to disease. However …

Inability to replicate many results has led to increasing scepticism about the value of simple
association study designs for detection of genetic variants contributing to common complex …

The scientific literature during the last ten years has seen an exponential increase in the
number of reports claiming links for genetic polymorphisms with a variety of medical …

BACKGROUND Respiratory syncytial virus (RSV) infects nearly all children by the end of
their second winter. Why some develop bronchiolitis is poorly understood; it is not known …

Liver fibrosis is a highly dynamic process in which multiple genes interact with
environmental factors. Recent human epidemiologic studies have identified possible …

Background Advances in human genetics could help us to assess prognosis on an
individual basis and to optimise the management of complex diseases. However, different …

The epidemiological investigation of the common open neural tube defects (NTDs),
anencephaly, and spina bifida, has a long history. The most significant finding from these …

Examines the potential clinical relevance of genetic variability on periodontitis. Contribution
of different genes to periodontitis; Examples of syndromic forms of periodontitis in which …

Genetic epidemiologic studies suggest a strong genetic influence on the outcome from
sepsis, and genetics may explain the wide variation in the individual response to infection …