Circadian and immunity cycle talk in cancer destination: from biological aspects to in silico analysis

M Mirian, A Hariri, M Yadollahi, M Kohandel - Cancers, 2022 - mdpi.com
Simple Summary The circadian cycle is a natural cycle of the body repeated every 24 h,
based on a day and night rhythm, and it affects many body processes. The present article …

Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy

AL Jenner, M Smalley, D Goldman, WF Goins… - Iscience, 2022 - cell.com
Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …

Investigating nano-sized tumor-derived extracellular vesicles in enhancing anti-PD-1 immunotherapy

H Abouali, M Przedborski, M Kohandel, M Poudineh - Nanoscale, 2024 - pubs.rsc.org
Anti-PD1 immune checkpoint blockade (ICB) has shown promising results for treating
several aggressive cancers, enhancing patient survival rates. The variability in clinical …

Nanoengineered disruption of heat shock protein 90 targets drug-induced resistance and relieves natural killer cell suppression in breast cancer

M Smalley, SK Natarajan, J Mondal, D Best… - Cancer research, 2020 - AACR
Drug-induced resistance, or tolerance, is an emerging yet poorly understood failure of
anticancer therapy. The interplay between drug-tolerant cancer cells and innate immunity …

[HTML][HTML] Sex-Related Differences in the Immune System Drive Differential Responses to Anti-PD-1 Immunotherapy

S Cotra, M Kohandel, M Przedborski - Biomolecules, 2024 - mdpi.com
Immune checkpoint inhibitors, such as anti-PD-1 antibodies, represent a significant
advancement in cancer immunotherapy, but their efficacy varies notably between …

[PDF][PDF] Systems biology models for cancer immunotherapy

S Cotra - 2024 - uwspace.uwaterloo.ca
Cancer is a complex disease that continues to affect millions of people around the world
every year. With ever-improving science and technology, several forms of treatment have …