[HTML][HTML] Toxin-induced experimental models of learning and memory impairment
Animal models for learning and memory have significantly contributed to novel strategies for
drug development and hence are an imperative part in the assessment of therapeutics …
drug development and hence are an imperative part in the assessment of therapeutics …
Animal models of dementia and cognitive dysfunction
Recent advances in the understanding of the pathophysiological mechanisms underlying
Alzheimer's disease and other cognitive deficits have pointed to novel strategies for drug …
Alzheimer's disease and other cognitive deficits have pointed to novel strategies for drug …
[HTML][HTML] Hyperglycemia-driven neuroinflammation compromises BBB leading to memory loss in both diabetes mellitus (DM) type 1 and type 2 mouse models
S Rom, V Zuluaga-Ramirez, S Gajghate, A Seliga… - Molecular …, 2019 - Springer
End organ injury in diabetes mellitus (DM) is driven by microvascular compromise (including
diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication …
diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication …
Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia
Diabetes is one of the risk factors for the development of vascular dementia (VD), leading to
endothelial dysfunction and cognitive impairment. Resveratrol has been shown to have …
endothelial dysfunction and cognitive impairment. Resveratrol has been shown to have …
Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: possible …
This study investigates the beneficial role of lisinopril, an angiotensin converting enzyme
inhibitor (ACEI) and telmisartan, an angiotensin receptor blocker (ARB), in …
inhibitor (ACEI) and telmisartan, an angiotensin receptor blocker (ARB), in …
Diabetes mellitus and vascular endothelial dysfunction: current perspectives
D Tousoulis, AM Kampoli… - Current vascular …, 2012 - ingentaconnect.com
Patients with diabetes mellitus (DM) have a high prevalence of coronary artery disease
(CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Endothelial …
(CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Endothelial …
Irisin attenuates neuroinflammation and prevents the memory and cognitive deterioration in streptozotocin‐induced diabetic mice
K Wang, F Song, K Xu, Z Liu, S Han… - Mediators of …, 2019 - Wiley Online Library
Diabetes mellitus (DM) patients experience memory and cognitive deficits. The mechanisms
underlying this dysfunction in the brain of DM patients are not fully understood, and …
underlying this dysfunction in the brain of DM patients are not fully understood, and …
[HTML][HTML] Pericyte loss in diseases
P Li, H Fan - Cells, 2023 - mdpi.com
Pericytes are specialized cells located in close proximity to endothelial cells within the
microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls …
microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls …
[HTML][HTML] Chemicals used for the induction of Alzheimer's disease-like cognitive dysfunctions in rodents
Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia,
characterised by multiple cognitive impairments and personality changes. Different methods …
characterised by multiple cognitive impairments and personality changes. Different methods …
[HTML][HTML] Glial and vascular cell regulation of the blood-brain barrier in diabetes
X Li, Y Cai, Z Zhang, J Zhou - Diabetes & Metabolism Journal, 2022 - ncbi.nlm.nih.gov
As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the
brain parenchyma and blood, and modulates communication between the brain and blood …
brain parenchyma and blood, and modulates communication between the brain and blood …