[HTML][HTML] Toxin-induced experimental models of learning and memory impairment

SV More, H Kumar, DY Cho, YS Yun… - International journal of …, 2016 - mdpi.com
Animal models for learning and memory have significantly contributed to novel strategies for
drug development and hence are an imperative part in the assessment of therapeutics …

Animal models of dementia and cognitive dysfunction

RK Sodhi, AS Jaggi, N Singh - Life Sciences, 2014 - Elsevier
Recent advances in the understanding of the pathophysiological mechanisms underlying
Alzheimer's disease and other cognitive deficits have pointed to novel strategies for drug …

[HTML][HTML] Hyperglycemia-driven neuroinflammation compromises BBB leading to memory loss in both diabetes mellitus (DM) type 1 and type 2 mouse models

S Rom, V Zuluaga-Ramirez, S Gajghate, A Seliga… - Molecular …, 2019 - Springer
End organ injury in diabetes mellitus (DM) is driven by microvascular compromise (including
diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication …

Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia

SS Gocmez, TD Şahin, Y Yazir, G Duruksu… - Physiology & …, 2019 - Elsevier
Diabetes is one of the risk factors for the development of vascular dementia (VD), leading to
endothelial dysfunction and cognitive impairment. Resveratrol has been shown to have …

Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: possible …

B Singh, B Sharma, AS Jaggi… - Journal of the Renin …, 2013 - journals.sagepub.com
This study investigates the beneficial role of lisinopril, an angiotensin converting enzyme
inhibitor (ACEI) and telmisartan, an angiotensin receptor blocker (ARB), in …

Diabetes mellitus and vascular endothelial dysfunction: current perspectives

D Tousoulis, AM Kampoli… - Current vascular …, 2012 - ingentaconnect.com
Patients with diabetes mellitus (DM) have a high prevalence of coronary artery disease
(CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Endothelial …

Irisin attenuates neuroinflammation and prevents the memory and cognitive deterioration in streptozotocin‐induced diabetic mice

K Wang, F Song, K Xu, Z Liu, S Han… - Mediators of …, 2019 - Wiley Online Library
Diabetes mellitus (DM) patients experience memory and cognitive deficits. The mechanisms
underlying this dysfunction in the brain of DM patients are not fully understood, and …

[HTML][HTML] Pericyte loss in diseases

P Li, H Fan - Cells, 2023 - mdpi.com
Pericytes are specialized cells located in close proximity to endothelial cells within the
microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls …

[HTML][HTML] Chemicals used for the induction of Alzheimer's disease-like cognitive dysfunctions in rodents

O Mahdi, MTH Baharuldin, NHM Nor… - Biomedical Research …, 2019 - biomedpress.org
Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia,
characterised by multiple cognitive impairments and personality changes. Different methods …

[HTML][HTML] Glial and vascular cell regulation of the blood-brain barrier in diabetes

X Li, Y Cai, Z Zhang, J Zhou - Diabetes & Metabolism Journal, 2022 - ncbi.nlm.nih.gov
As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the
brain parenchyma and blood, and modulates communication between the brain and blood …