Gene expression is regulated at many levels including co-or post-transcriptionally, where
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …

The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

The chemical nature and precise position of posttranslational modifications (PTMs) in
proteins or peptides are crucial for various severe diseases, such as cancer. State-of-the-art …

Androgen deprivation therapy has a central role in the treatment of advanced prostate
cancer, often causing initial tumour remission before increasing independence from signal …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Inhibition of epigenetic regulators by small molecules is an attractive strategy for cancer
treatment. Recently, we characterised the role of lysine methyltransferase 9 (KMT9) in …

The highly homologous protein lysine methyltransferases G9a and GLP, which catalyze
mono-and dimethylation of histone H3 lysine 9 (H3K9), have been implicated in various …

Despite the discovery of modified nucleic acids nearly 75 years ago, their biological
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …

Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent an
important layer of gene expression regulation through their ability to fine-tune mRNA …