Chemical complementarity of breast cancer resident, T-cell receptor CDR3 domains and the cancer antigen, ARMC3, is associated with higher levels of survival and …
N Pakasticali, A Chobrutskiy, DN Patel… - Cancer …, 2023 - journals.sagepub.com
Introduction: One of the most pressing goals for cancer immunotherapy at this time is the
identification of actionable antigens. Methods: This study relies on the following …
identification of actionable antigens. Methods: This study relies on the following …
IGL CDR3 Hydropathy and antigen chemical complementarity associated with greater disease-free survival in lung adenocarcinoma: implications for gender …
SV Charkowick, TI Huda, DN Patel, M Yeagley… - Biochemical …, 2024 - Springer
With lung cancer remaining a challenging disease, new approaches to biomarker discovery
and therapy development are needed. Recent immunogenomics, adaptive immune receptor …
and therapy development are needed. Recent immunogenomics, adaptive immune receptor …
Blood-based T cell receptor anti-viral CDR3s are associated with worse overall survival for neuroblastoma
With the advent of large collections of adaptive immune receptor recombination reads
representing cancer, there is the opportunity to further investigate the adaptive immune …
representing cancer, there is the opportunity to further investigate the adaptive immune …
Exploiting big data survival information to unify risk-stratification related, adaptive immune receptor parameters for multiple myeloma
HJ Wolmarans, VR Barker, A Chobrutskiy… - Genes & …, 2023 - nature.com
With the improvement of treatment options, multiple myeloma related life expectancy has
been prolonged, but the disease remains largely incurable. Immunotherapy is a growing …
been prolonged, but the disease remains largely incurable. Immunotherapy is a growing …
TRB CDR3 chemical complementarity with HBV epitopes correlates with increased hepatocellular carcinoma, disease‐free survival
JJ Song, A Chobrutskiy, BI Chobrutskiy… - Journal of Medical …, 2023 - Wiley Online Library
The liver is a site of immune privilege, compared with the bladder and skin, for example. To
study this attenuation of the immune response in the cancer setting, we compared quantities …
study this attenuation of the immune response in the cancer setting, we compared quantities …
Electrostatic Complementarities of Glioblastoma-Resident T-Cell Receptors and Cancer Testis Antigens Linked to Poor Outcomes and High Levels of Sphingosine …
MA Arias, KJ Cios, DB Kacsoh, BE Montgomery… - Biology, 2023 - mdpi.com
Simple Summary The chemical complementarity of glioblastoma, tumor-resident T-cell
receptors and cancer testis antigens were associated with a worse outcome. Additionally …
receptors and cancer testis antigens were associated with a worse outcome. Additionally …
Chemical Complementarity of Tumor Resident, Adaptive Immune Receptor CDR3s and Previously Defined Hepatitis C Virus Epitopes Correlates with Improved …
JJ Song, A Chobrutskiy, BI Chobrutskiy, KJ Cios… - Viral …, 2023 - liebertpub.com
To better understand how adaptive immune receptors (IRs) in hepatocellular carcinoma
(HCC) microenvironments are related to disease outcomes, we employed a chemical …
(HCC) microenvironments are related to disease outcomes, we employed a chemical …
[HTML][HTML] An immunoinformatics assessment of the cancer testis antigen, DDX53, as a potential early esophageal cancer antigen
P Cheng, KJ Cios, M Varkhedi, VR Barker… - …, 2023 - ncbi.nlm.nih.gov
T-lymphocytes have been implicated in facilitating a pro-inflammatory, pro-tumorigenic
microenvironment that worsens prognosis for esophageal carcinoma (ESCA). In this study …
microenvironment that worsens prognosis for esophageal carcinoma (ESCA). In this study …
The presence of intratumoral Porphyromonas gingivalis correlates with a previously defined pancreatic adenocarcinoma, immune cell expression phenotype and with …
JC Kinskey, TI Huda, EC Gozlan, JU Quach… - …, 2023 - academic.oup.com
The association between pancreatic adenocarcinoma (PAAD) and the pancreatic
microbiome is not fully understood, although bacteria may decrease the effectiveness of …
microbiome is not fully understood, although bacteria may decrease the effectiveness of …
CMV as a factor in the development of Alzheimer's disease?
G Blanck, TI Huda, BI Chobrutskiy, A Chobrutskiy - Medical Hypotheses, 2023 - Elsevier
Cytomegalovirus (CMV) infection has been associated with poorer cognitive abilities, and
there has recently been an association of T cell receptor alpha (TRA) complementarity …
there has recently been an association of T cell receptor alpha (TRA) complementarity …