Chemical complementarity of breast cancer resident, T-cell receptor CDR3 domains and the cancer antigen, ARMC3, is associated with higher levels of survival and …

N Pakasticali, A Chobrutskiy, DN Patel… - Cancer …, 2023 - journals.sagepub.com
Introduction: One of the most pressing goals for cancer immunotherapy at this time is the
identification of actionable antigens. Methods: This study relies on the following …

IGL CDR3 Hydropathy and antigen chemical complementarity associated with greater disease-free survival in lung adenocarcinoma: implications for gender …

SV Charkowick, TI Huda, DN Patel, M Yeagley… - Biochemical …, 2024 - Springer
With lung cancer remaining a challenging disease, new approaches to biomarker discovery
and therapy development are needed. Recent immunogenomics, adaptive immune receptor …

Blood-based T cell receptor anti-viral CDR3s are associated with worse overall survival for neuroblastoma

DB Kacsoh, MJ Diaz, EC Gozlan, A Sahoo… - Journal of Cancer …, 2023 - Springer
With the advent of large collections of adaptive immune receptor recombination reads
representing cancer, there is the opportunity to further investigate the adaptive immune …

Exploiting big data survival information to unify risk-stratification related, adaptive immune receptor parameters for multiple myeloma

HJ Wolmarans, VR Barker, A Chobrutskiy… - Genes & …, 2023 - nature.com
With the improvement of treatment options, multiple myeloma related life expectancy has
been prolonged, but the disease remains largely incurable. Immunotherapy is a growing …

TRB CDR3 chemical complementarity with HBV epitopes correlates with increased hepatocellular carcinoma, disease‐free survival

JJ Song, A Chobrutskiy, BI Chobrutskiy… - Journal of Medical …, 2023 - Wiley Online Library
The liver is a site of immune privilege, compared with the bladder and skin, for example. To
study this attenuation of the immune response in the cancer setting, we compared quantities …

Electrostatic Complementarities of Glioblastoma-Resident T-Cell Receptors and Cancer Testis Antigens Linked to Poor Outcomes and High Levels of Sphingosine …

MA Arias, KJ Cios, DB Kacsoh, BE Montgomery… - Biology, 2023 - mdpi.com
Simple Summary The chemical complementarity of glioblastoma, tumor-resident T-cell
receptors and cancer testis antigens were associated with a worse outcome. Additionally …

Chemical Complementarity of Tumor Resident, Adaptive Immune Receptor CDR3s and Previously Defined Hepatitis C Virus Epitopes Correlates with Improved …

JJ Song, A Chobrutskiy, BI Chobrutskiy, KJ Cios… - Viral …, 2023 - liebertpub.com
To better understand how adaptive immune receptors (IRs) in hepatocellular carcinoma
(HCC) microenvironments are related to disease outcomes, we employed a chemical …

[HTML][HTML] An immunoinformatics assessment of the cancer testis antigen, DDX53, as a potential early esophageal cancer antigen

P Cheng, KJ Cios, M Varkhedi, VR Barker… - …, 2023 - ncbi.nlm.nih.gov
T-lymphocytes have been implicated in facilitating a pro-inflammatory, pro-tumorigenic
microenvironment that worsens prognosis for esophageal carcinoma (ESCA). In this study …

The presence of intratumoral Porphyromonas gingivalis correlates with a previously defined pancreatic adenocarcinoma, immune cell expression phenotype and with …

JC Kinskey, TI Huda, EC Gozlan, JU Quach… - …, 2023 - academic.oup.com
The association between pancreatic adenocarcinoma (PAAD) and the pancreatic
microbiome is not fully understood, although bacteria may decrease the effectiveness of …

CMV as a factor in the development of Alzheimer's disease?

G Blanck, TI Huda, BI Chobrutskiy, A Chobrutskiy - Medical Hypotheses, 2023 - Elsevier
Cytomegalovirus (CMV) infection has been associated with poorer cognitive abilities, and
there has recently been an association of T cell receptor alpha (TRA) complementarity …