Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Electrical stimulation for the treatment of spinal cord injuries: A review of the cellular and molecular mechanisms that drive functional improvements

RM Dorrian, CF Berryman, A Lauto… - Frontiers in Cellular …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a devastating condition that causes severe loss of motor, sensory
and autonomic functions. Additionally, many individuals experience chronic neuropathic …

The roles and applications of neural stem cells in spinal cord injury repair

W Guo, X Zhang, J Zhai, J Xue - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Spinal cord injury (SCI), which has no current cure, places a severe burden on patients.
Stem cell-based therapies are considered promising in attempts to repair injured spinal …

[HTML][HTML] Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair

Q Wang, H Zhang, H Xu, Y Zhao, Z Li, J Li, H Wang… - Theranostics, 2018 - ncbi.nlm.nih.gov
Proper selection and effective delivery of combination drugs targeting multiple
pathophysiological pathways key to spinal cord injury (SCI) hold promise to address the thus …

[HTML][HTML] Recovery of paralyzed limb motor function in canine with complete spinal cord injury following implantation of MSC-derived neural network tissue

GH Wu, HJ Shi, MT Che, MY Huang, QS Wei, B Feng… - Biomaterials, 2018 - Elsevier
We have reported previously that bone marrow mesenchymal stem cell (MSC)-derived
neural network scaffold not only survived in the injury/graft site of spinal cord but also served …

Experimental spinal cord injury and behavioral tests in laboratory rats

RU Ahmed, M Alam, YP Zheng - Heliyon, 2019 - cell.com
Traumatic spinal cord injury (SCI) results in some serious neurophysiological consequences
that alter healthy body functions and devastate the quality of living of individuals. To find a …

Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering

S Mobini, YH Song, MW McCrary, CE Schmidt - Biomaterials, 2019 - Elsevier
The technologies related to ex vivo models and lab-on-a-chip devices for studying the
regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural …

The comparative effects of mesenchymal stem cell transplantation therapy for spinal cord injury in humans and animal models: a systematic review and meta-analysis

LDV Johnson, MR Pickard, WEB Johnson - Biology, 2021 - mdpi.com
Simple Summary The effects of mesenchymal stem cell (MSC) transplants on functional
recovery after spinal cord injury have been compared in humans and animal models. Data …

[HTML][HTML] The regenerative effect of trans-spinal magnetic stimulation after spinal cord injury: Mechanisms and pathways underlying the effect

C Chalfouh, C Guillou, J Hardouin, Q Delarue, X Li… - …, 2020 - Elsevier
Spinal cord injury (SCI) leads to a loss of sensitive and motor functions. Currently, there is no
therapeutic intervention offering a complete recovery. Here, we report that repetitive trans …