Inflammasomes and pyroptosis as therapeutic targets for COVID-19

JKY Yap, M Moriyama, A Iwasaki - The Journal of Immunology, 2020 - journals.aai.org
The inflammatory response to severe acute respiratory syndrome–related coronavirus 2
infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients …

NLRP3 inflammasome as a key driver of vascular disease

M Takahashi - Cardiovascular research, 2022 - academic.oup.com
Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …

Kawasaki disease: pathophysiology and insights from mouse models

M Noval Rivas, M Arditi - Nature Reviews Rheumatology, 2020 - nature.com
Kawasaki disease is an acute febrile illness and systemic vasculitis of unknown aetiology
that predominantly afflicts young children, causes coronary artery aneurysms and can result …

Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction

X Zhou, J Li, J Guo, B Geng, W Ji, Q Zhao, J Li, X Liu… - Microbiome, 2018 - Springer
Background Post-infarction cardiovascular remodeling and heart failure are the leading
cause of myocardial infarction (MI)-driven death during the past decades. Experimental …

Kawasaki disease

JW Newburger, M Takahashi, JC Burns - Journal of the American College …, 2016 - jacc.org
Kawasaki disease is an acute, self-limited vasculitis of unknown etiology that occurs
predominantly in infants and children. If not treated early with high-dose intravenous …

[HTML][HTML] Kawasaki disease: pathophysiology and insights from mouse models

MN Rivas, M Arditi - Nature reviews. Rheumatology, 2020 - ncbi.nlm.nih.gov
Kawasaki disease is an acute febrile illness and systemic vasculitis of unknown aetiology
that predominantly afflicts young children, causes coronary artery aneurysms and can result …

Pyroptosis: a new regulating mechanism in cardiovascular disease

N Ji, Z Qi, Y Wang, X Yang, Z Yan, M Li… - Journal of …, 2021 - Taylor & Francis
Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …

Platelets fuel the inflammasome activation of innate immune cells

V Rolfes, LS Ribeiro, I Hawwari, L Böttcher, N Rosero… - Cell reports, 2020 - cell.com
The inflammasomes control the bioactivity of pro-inflammatory cytokines of the interleukin
(IL)-1 family. The inflammasome assembled by NLRP3 has been predominantly studied in …

Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies

G Cavalli, CA Dinarello - Rheumatology, 2015 - academic.oup.com
The inflammatory cytokines IL-1α and IL-1β orchestrate local and systemic inflammatory
responses underlying a broad spectrum of diseases. Three agents for reducing IL-1 …

NLRP3 inflammasome mediates immune-stromal interactions in vasculitis

RA Porritt, D Zemmour, M Abe, Y Lee… - Circulation …, 2021 - Am Heart Assoc
Rationale: NLRP3 (NLR family pyrin domain containing 3) activation and IL-1β (interleukin-
1β) production are implicated in Kawasaki disease (KD) pathogenesis; however, a detailed …