Dendritic cells (DCs) play a central role in the regulation of the balance between CD8 T cell
immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 …

As the sentinels of the immune system, dendritic cells (DCs) play a critical role in initiating
and regulating antigen-specific immune responses. Cross-priming, a process that DCs …

Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves
response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 …

Simple Summary Dendritic cells (DCs)-based cancer vaccines have not succeeded in
generating significant clinical responses despite their capacity to induce host anti-tumor …

Cancer immunotherapy can successfully promote long-term anticancer immune responses,
although there is still only a limited number of patients who benefit from such treatment, and …

The complex tumor microenvironment (TME) plays a vital role in cancer development and
dramatically determines the efficacy of immunotherapy. Tertiary lymphoid structures (TLSs) …

As the most potent professional antigen presenting cells, dendritic cells (DCs) have the
ability to activate both naive CD4 and CD8 T cells. Recognized for their exceptional ability to …

In cancer, lymph nodes (LNs) coordinate tumor antigen presentation necessary for effective
antitumor immunity, both at the levels of local cellular interactions and tissue-level …

We have previously reported that direct injection of dendritic cells (DC) engineered to
express the Type-1 transactivator Tbet (ie, DC. Tbet) into murine tumors results in antitumor …

Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized
lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic …