Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Emerging antimicrobial-resistant high-risk Klebsiella pneumoniae clones ST307 and ST147

G Peirano, L Chen, BN Kreiswirth… - Antimicrobial agents and …, 2020 - Am Soc Microbiol
There is an enormous global public health burden due to antimicrobial-resistant (AMR)
Klebsiella pneumoniae high-risk clones. K. pneumoniae ST307 and ST147 are recent …

A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron …

SE Heiden, NO Hübner, JA Bohnert, CD Heidecke… - Genome Medicine, 2020 - Springer
Abstract Background Antibiotic-resistant Klebsiella pneumoniae are a major cause of
hospital-and community-acquired infections, including sepsis, liver abscess, and …

Successive Emergence of Ceftazidime-Avibactam Resistance through Distinct Genomic Adaptations in blaKPC-2-Harboring Klebsiella pneumoniae Sequence Type …

MJ Giddins, N Macesic, MK Annavajhala… - Antimicrobial agents …, 2018 - Am Soc Microbiol
ABSTRACT Ceftazidime-avibactam (CAZ-AVI) is a promising novel treatment for infections
caused by carbapenem-resistant Enterobacteriaceae (CRE). Despite improved treatment …

Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

KL Wyres, J Hawkey, MAK Hetland… - Journal of …, 2019 - academic.oup.com
Objectives Recent reports indicate the emergence of a new carbapenemase-producing
Klebsiella pneumoniae clone, ST307. We sought to better understand the global …

Evolutionary trajectories toward ceftazidime-avibactam resistance in Klebsiella pneumoniae clinical isolates

A Carattoli, G Arcari, G Bibbolino, F Sacco… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
ABSTRACT From January 2019 to April 2020, 32 KPC-producing, ceftazidime-avibactam
(CZA)-resistant Klebsiella pneumoniae strains were isolated in a university hospital in …

Prevalence and incidence of carbapenem-resistant K. pneumoniae colonization: systematic review and meta-analysis

T Tesfa, H Mitiku, M Edae, N Assefa - Systematic reviews, 2022 - Springer
Background Klebsiella pneumoniae is a gram-negative rod belonging to the order
Enterobacterales and having a wide distribution in the environment, including the human …

Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses

WP Herridge, P Shibu, J O'Shea… - Journal of medical …, 2020 - microbiologyresearch.org
Klebsiella spp. are commensals of the human microbiota, and a leading cause of
opportunistic nosocomial infections. The incidence of multidrug resistant (MDR) strains of …

Antimicrobial-Resistant Klebsiella pneumoniae Carriage and Infection in Specialized Geriatric Care Wards Linked to Acquisition in the Referring Hospital

CL Gorrie, M Mirceta, RR Wick, LM Judd… - Clinical infectious …, 2018 - academic.oup.com
Background Klebsiella pneumoniae is a leading cause of extended-spectrum β-lactamase
(ESBL)–producing hospital-associated infections, for which elderly patients are at increased …

ESBL plasmids in Klebsiella pneumoniae: diversity, transmission and contribution to infection burden in the hospital setting

J Hawkey, KL Wyres, LM Judd, T Harshegyi… - Genome Medicine, 2022 - Springer
Background Resistance to third-generation cephalosporins, often mediated by extended-
spectrum beta-lactamases (ESBLs), is a considerable issue in hospital-associated infections …