Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In
animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase …

The notion that cell shape and spreading can regulate cell proliferation has evolved over
several years, but only recently has this been linked to forces from within and upon the cell …

The polo-like kinase 1 (PLK1) acts in concert with cyclin-dependent kinase 1–cyclin B1 and
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …

Polo-like kinases (Plks) are potent regulators of M phase that are conserved from yeasts to
humans. Their roles in mitotic entry, spindle pole functions and cytokinesis are broadly …

Human papillomaviruses (HPVs) are DNA viruses associated with major human cancers. As
such there is a strong interest in developing new means, such as vaccines and microbicides …

Commitment to mitosis must be tightly coordinated with DNA replication to preserve genome
integrity. While we have previously established that the timely activation of CyclinB1-Cdk1 in …

Purpose: Antimitotic chemotherapy remains a cornerstone of multimodality treatment for
locally advanced and metastatic cancers. To identify novel mitosis-specific agents with …

The cyclin B–Cdk1 kinase triggers mitosis in most eukaryotes. In animal cells, cyclin B
shuttles between the nucleus and cytoplasm in interphase before rapidly accumulating in …

The network of actin filaments is one of the crucial cytoskeletal structures contributing to the
morphological framework of a cell and which participates in the dynamic regulation of …