Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the
extracellular matrix and the basement membrane. Thus, these enzymes regulate airway …

Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …

Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …

Enantioenriched unnatural amino acids represent a prevalent motif in organic chemistry,
with profound applications in biochemistry, medicinal chemistry, and materials science …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality
globally and the risk of developing lung cancer is six times greater in individuals with COPD …

Background Electronic cigarette (e-cigarette) vapour is gaining popularity as an alternative
to tobacco smoking and can induce acute lung injury. However, the specific role of nicotine …

Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important
roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 …

Abstract Background Alveolar macrophages (AMs) and AM-produced matrix
metalloprotease (MMP)-12 are known to play critical roles in the pathogenesis of chronic …

We report on an innovative ligand discovery strategy based on protein NMR-based
screening of a combinatorial library of∼ 125,000 compounds that was arranged in 96 …

Idiopathic pulmonary fibrosis (IPF) is a lethal disease with limited therapeutic options and a
particularly poor prognosis. Matrix metalloproteinases (MMPs), promising targets for the …