Androgens, acting through the androgen receptor (AR), are responsible for the development
of the male phenotype during embryogenesis, the achievement of sexual maturation at …

Folates, also known as B9 vitamins, serve as donors and acceptors in one-carbon (C1)
transfer reactions. The latter are involved in synthesis of many important biomolecules, such …

Histones undergo several different post-translational modifications that control a variety of
physiological processes. These covalent modifications show substantial cross-regulation …

Within the vast landscape of histone modifications lysine methylation has gained increasing
attention because of its profound regulatory potential. The methylation of lysine residues on …

Dynamic histone H3K4 methylation is an important epigenetic component of transcriptional
regulation. However, most of our current understanding of this histone mark is confined to …

Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a
long-lasting reduction in K+ channel expression in the dorsal root ganglion (DRG), but little …

Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy in
which no mutation of pathogenic gene (s) has been identified. Instead, the disease is, in …

Estrogen receptor α (ER) is a ligand-dependent transcription factor. Upon binding estrogen,
ER recruits coactivator complexes with histone acetyltransferase or methyltransferase …

Histone modifications have important roles in transcriptional control, mitosis and
heterochromatin formation. G9a and G9a-like protein (GLP) are euchromatin-associated …

PPARγ promotes adipogenesis while Wnt proteins inhibit adipogenesis. However, the
mechanisms that control expression of these positive and negative master regulators of …