Mice are the most commonly used species in preclinical research on the pathophysiology of
metabolic diseases. Although they are extremely useful for identifying pathways …

Chronic kidney disease (CKD) is an incurable disease in which renal function gradually
declines, resulting in no noticeable symptoms during the early stages and a life-threatening …

Experiments involving food restriction are common practice in metabolic research. Under
fasted conditions, mice supplement their diet with cage bedding. We aimed at identifying …

The reproducibility of pre-clinical research is an important concern that is now being voiced
by constituencies that include the National Institutes of Health, the pharmaceutical industry …

Rodent husbandry requires careful consideration of environmental factors that may impact
colony performance and subsequent physiological studies. Of note, recent reports have …

Rodent models are invaluable to understanding health and disease in many areas of
biomedical research. Unfortunately, many models suffer from lack of phenotype …

Diet plays a substantial role in the etiology, progression, and treatment of chronic disease
and is best considered as a multifaceted set of modifiable input variables with pleiotropic …

As the editors of several journals, we have joined forces to highlight the importance of
providing essential details related to animal experiments, particularly for studies that include …

Aims/hypothesis Human islets from type 2 diabetic donors are reportedly 80% deficient in
the p21 (Cdc42/Rac)-activated kinase, PAK1. PAK1 is implicated in beta cell function and …

In 1989 ILAR published a list and description of immunodeficient rodents used in research.
Since then, advances in understanding of molecular mechanisms; recognition of genetic …