Off-label use of medication may be presented in these guidelines if a sufficient level of
evidence shows that it can be considered medically appropriate to a given condition and if …

Diabetic foot ulcers (DFU) are a major source of preventable morbidity in adults with
diabetes. Consequences of foot ulcers include decline in functional status, infection …

Importance Approximately 18.6 million people worldwide are affected by a diabetic foot ulcer
each year, including 1.6 million people in the United States. These ulcers precede 80% of …

The American Diabetes Association (ADA)“Standards of Care in Diabetes” includes the
ADA's current clinical practice recommendations and is intended to provide the components …

Lower extremity peripheral artery disease (PAD) affects> 230 million adults worldwide and is
associated with increased risk of various adverse clinical outcomes (other cardiovascular …

• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Background Patients with chronic limb-threatening ischemia (CLTI) require revascularization
to improve limb perfusion and thereby limit the risk of amputation. It is uncertain whether an …

Atherosclerotic lower extremity peripheral artery disease (PAD) is increasingly recognized
as an important cause of cardiovascular morbidity and mortality that affects> 230 million …

Background Chronic limb-threatening ischaemia is the severest manifestation of peripheral
arterial disease and presents with ischaemic pain at rest or tissue loss (ulceration …

Abstract The Wound Healing Foundation (WHF) recognised a need for an unbiased
consensus on the best treatment of chronic wounds. A panel of 13 experts were invited to a …