Alzheimer's (or Alzheimer) disease (AD) is the most prevalent subset of dementia, affecting
elderly populations worldwide. The cumulative costs of the AD care are rapidly accelerating …

Cognitive decline is a major deficit that arises with age in humans. While some research on
the underlying causes of these problems can be done in humans, harnessing the strengths …

Autophagy is a cellular degradation pathway essential for neuronal health and function.
Autophagosome biogenesis occurs at synapses, is locally regulated, and increases in …

KIF1A is a kinesin superfamily motor protein that transports synaptic vesicle precursors in
axons. Cargo binding stimulates the dimerization of KIF1A molecules to induce processive …

Background: Aging has often been linked to age-related vascular disorders. The elucidation
of the putative genes and pathways underlying vascular aging likely provides useful insights …

E-cigarettes, also known as electronic nicotine delivery systems (ENDS), are mainly used
among adolescents and young adults. Similar to traditional cigarettes, different …

Mitochondria play fundamental roles within cells, including energy provision, calcium
homeostasis, and the regulation of apoptosis. The transport of mitochondria by microtubule …

Tbr1 is a high-confidence autism spectrum disorder (ASD) gene encoding a transcription
factor with distinct pre-and postnatal functions. Postnatally, Tbr1 conditional knockout (CKO) …

Regulation of the microtubule cytoskeleton is crucial for the development and maintenance
of neuronal architecture, and recent studies have highlighted the significance of regulated …

Fast axonal transport is crucial for neuronal function and is driven by kinesins and
cytoplasmic dynein. Here, we investigated the role of kinesin-1 in dense core vesicle (DCV) …