Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer
Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
Endogenous retroviral promoter exaptation in human cancer
Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of …
expression or mutational activation of oncogenes, as well as suppression/inactivation of …
Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci
C Philippe, DB Vargas-Landin, AJ Doucet… - Elife, 2016 - elifesciences.org
LINE-1 (L1) retrotransposons represent approximately one sixth of the human genome, but
only the human-specific L1HS-Ta subfamily acts as an endogenous mutagen in modern …
only the human-specific L1HS-Ta subfamily acts as an endogenous mutagen in modern …
The significance of epigenetic alterations in lung carcinogenesis
E Brzeziańska, A Dutkowska, A Antczak - Molecular biology reports, 2013 - Springer
Lung cancer is recognized as a leading cause of cancer-related death worldwide and its
frequency is still increasing. The prognosis in lung cancer is poor and limited by the …
frequency is still increasing. The prognosis in lung cancer is poor and limited by the …
Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers
The outbreak of vaping-related severe lung injuries and deaths and the epidemic of teen
vaping in the US underscore the urgent need for determining the biological consequences …
vaping in the US underscore the urgent need for determining the biological consequences …
Selective changes of retroelement expression in human prostate cancer
W Goering, T Ribarska, WA Schulz - Carcinogenesis, 2011 - academic.oup.com
Retroelements constitute a large part of the human genome. These sequences are mostly
silenced in normal cells, but genome-wide DNA hypomethylation in cancers might lead to …
silenced in normal cells, but genome-wide DNA hypomethylation in cancers might lead to …
Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma
Remnants of ancient transposable elements (TEs) are abundant in mammalian genomes.
These sequences harbor multiple regulatory motifs and hence are capable of influencing …
These sequences harbor multiple regulatory motifs and hence are capable of influencing …
Overexpression of piRNA pathway genes in epithelial ovarian cancer
SL Lim, C Ricciardelli, MK Oehler, IMD De Arao Tan… - PloS one, 2014 - journals.plos.org
The importance of the Piwi-interacting RNA (piRNA) pathway for germ cell maintenance,
genome integrity, DNA methylation and retrotransposon control raises possible roles of this …
genome integrity, DNA methylation and retrotransposon control raises possible roles of this …
[HTML][HTML] Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression
A Gualtieri, F Andreola, I Sciamanna… - Oncotarget, 2013 - ncbi.nlm.nih.gov
In higher eukaryotic genomes, Long Interspersed Nuclear Element 1 (LINE-1)
retrotransposons and endogenous retroviruses represent large families of repeated …
retrotransposons and endogenous retroviruses represent large families of repeated …
Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs
N Nüsgen, W Goering, A Dauksa, A Biswas… - Clinical …, 2015 - Springer
Background Hypomethylation of long interspersed element (LINE)-1 has been observed in
tumorigenesis when using degenerate assays, which provide an average across all repeats …
tumorigenesis when using degenerate assays, which provide an average across all repeats …