Age-associated B cells

MP Cancro - Annual review of immunology, 2020 - annualreviews.org
The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …

[HTML][HTML] Targeting immune dysfunction in aging

S Borgoni, KS Kudryashova, K Burka… - Ageing research …, 2021 - Elsevier
Human aging is a multifactorial phenomenon that affects numerous organ systems and
cellular processes, with the immune system being one of the most dysregulated …

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

E Zumaquero, SL Stone, CD Scharer, SA Jenks… - Elife, 2019 - elifesciences.org
Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet
promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the …

B cell dysfunction associated with aging and autoimmune diseases

S Ma, C Wang, X Mao, Y Hao - Frontiers in immunology, 2019 - frontiersin.org
Impaired humoral responses, as well as an increased propensity for autoimmunity, play an
important role in the development of immune system dysfunction associated with aging …

T‐bet+ memory B cells: Generation, function, and fate

JJ Knox, A Myles, MP Cancro - Immunological reviews, 2019 - Wiley Online Library
B cells expressing the transcription factor T‐bet have emerged as participants in a number of
protective and pathogenic immune responses. T‐bet+ B cells characteristically differentiate …

Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade

JC Yam-Puc, Z Hosseini, EC Horner, PP Gerber… - Nature …, 2023 - nature.com
Age-associated B cells (ABC) accumulate with age and in individuals with different
immunological disorders, including cancer patients treated with immune checkpoint …

[HTML][HTML] COVID‐19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age‐associated B cells

A Sachinidis, A Garyfallos - International journal of rheumatic …, 2022 - ncbi.nlm.nih.gov
4| CONCLUSIONS In this article, we discuss the probability of ABC-mediated autoimmunity
(flare or new-onset) following COVID-19 vaccination. We find it important to mention here …

[HTML][HTML] Epstein–Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseases

L Bogers, KL Kuiper, J Smolders, J Rip, MM van Luijn - Immunology letters, 2023 - Elsevier
B cells expressing the transcription factor T-bet are found to have a protective role in viral
infections, but are also considered major players in the onset of different types of …

Tuberculosis and autoimmunity

IV Belyaeva, AN Kosova, AG Vasiliev - Pathophysiology, 2022 - mdpi.com
Tuberculosis remains a common and dangerous chronic bacterial infection worldwide. It is
long-established that pathogenesis of many autoimmune diseases is mainly promoted by …

Plasmodium-specific atypical memory B cells are short-lived activated B cells

D Perez-Mazliah, PJ Gardner, E Schweighoffer… - Elife, 2018 - elifesciences.org
A subset of atypical memory B cells accumulates in malaria and several infections,
autoimmune disorders and aging in both humans and mice. It has been suggested these …