Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …

Thromboxane A2 (TXA2), an unstable arachidonic acid metabolite, elicits diverse
physiological/pathophysiological actions, including platelet aggregation and smooth muscle …

Prostanoids are arachidonic acid metabolites and are generally accepted to play pivotal
functions in amongst others inflammation, platelet aggregation, and vasoconstriction …

Thromboxane A2 (TXA2) receptor is a key molecule in hemostasis as its abnormality leads
to bleeding disorders. Two isoforms of the human TXA2 receptor have been cloned; one …

Many receptors that couple to heterotrimeric guanine-nucleotide binding proteins (G
proteins) have been shown to mediate rapid activation of the mitogen-activated protein …

Mammalian cells respond to external stimuli by activation of a variety of signal transduction
pathways, which culminate in stereotypical responses, such as proliferation, growth arrest …

Thromboxane A2 receptors (TPs) are widely distributed among different organ systems and
have been localized on both cell membranes and intracellular structures. Following the …

RECEPTORS coupled to heterotrimeric GTP-binding proteins (G proteins) comprise the
largest known family of cell surface receptors and mediate cellular responses to a diverse …

The smooth muscle cell is the sole cell type normally found in the media of mammalian
arteries. In the adult, it is a terminally differentiated cell that expresses cytoskeletal marker …

Pulmonary hypertension is a multifactorial disease characterized by sustained elevation of
pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP). Central to the …