Vimentin diversity in health and disease

F Danielsson, MKK Peterson, H Caldeira Araújo… - Cells, 2018 - mdpi.com
Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …

GFAP in health and disease

J Middeldorp, EM Hol - Progress in neurobiology, 2011 - Elsevier
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

Impairment of the ubiquitin-proteasome system by protein aggregation

NF Bence, RM Sampat, RR Kopito - Science, 2001 - science.org
Intracellular deposition of aggregated and ubiquitylated proteins is a prominent
cytopathological feature of most neurodegenerative disorders. Whether protein aggregates …

[HTML][HTML] Ageing and vision: structure, stability and function of lens crystallins

H Bloemendal, W de Jong, R Jaenicke… - Progress in biophysics …, 2004 - Elsevier
The α-, β-and γ-crystallins are the major protein components of the vertebrate eye lens, α-
crystallin as a molecular chaperone as well as a structural protein, β-and γ-crystallins as …

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor α by phosphorylation

T Rogalla, M Ehrnsperger, X Preville… - Journal of Biological …, 1999 - ASBMB
The small heat shock proteins (sHsps) from human (Hsp27) and mouse (Hsp25) form large
oligomers which can act as molecular chaperones in vitro and protect cells from heat shock …

Alpha-crystallin

J Horwitz - Experimental eye research, 2003 - Elsevier
Alpha A and alpha B-crystallins are a major protein component of the mammalian eye lens.
Being a member of the small heat-shock protein family they possess chaperone-like …

[HTML][HTML] The growing world of small heat shock proteins: from structure to functions

S Carra, S Alberti, PA Arrigo, JL Benesch… - Cell Stress and …, 2017 - Elsevier
Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental
roles in cell biology. sHSPs are key components of the cellular protein quality control …

Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death

J Acunzo, M Katsogiannou, P Rocchi - … journal of biochemistry & cell biology, 2012 - Elsevier
Hsp27, αB-crystallin and HSP22 are ubiquitous small heat shock proteins (sHsp) whose
expression is induced in response to a wide variety of unfavorable physiological and …

[HTML][HTML] Binding of non‐native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation

M Ehrnsperger, S Gräber, M Gaestel… - The EMBO journal, 1997 - embopress.org
Small heat shock proteins (sHsps) are a conserved and ubiquitous protein family. Their
ability to convey thermoresistance suggests their participation in protecting the native …

Crystallins in the eye: function and pathology

UP Andley - Progress in retinal and eye research, 2007 - Elsevier
Crystallins are the predominant structural proteins in the lens that are evolutionarily related
to stress proteins. They were first discovered outside the vertebrate eye lens by Bhat and …