Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …

Pioneering electron microscopy studies defined two primary populations of ribosomes in
eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the …

POTENTIAL CONFLICT OF INTEREST: The University of Virginia has filed patent
applications related to new technologies for the rapid production of vaccines, and Dr …

Replication of Mononegavirales occurs in viral factories which form inclusions in the host-
cell cytoplasm. For rabies virus, those inclusions are called Negri bodies (NBs). We report …

Vaccinia virus produces four different types of virion from each infected cell called
intracellular mature virus (IMV), intracellular enveloped virus (IEV), cell-associated …

Genome replication and assembly of viruses often takes place in specific intracellular
compartments where viral components concentrate, thereby increasing the efficiency of the …

The endoplasmic reticulum (ER) is the largest intracellular organelle. It forms a complex
network of continuous sheets and tubules, extending from the nuclear envelope (NE) to the …

Viruses reshape the organization of the cell interior to achieve different steps of their cellular
cycle. Particularly, viral replication and assembly often take place in viral factories where …

Poxviruses comprise a large family of viruses characterized by a large, linear dsDNA
genome, a cytoplasmic site of replication and a complex virion morphology. The most …

Coronaviruses (CoVs) assemble by budding into the lumen of the intermediate compartment
(IC) at the endoplasmic reticulum (ER)-Golgi interface. However, why CoVs have chosen the …