The tumour suppressor p53 is activated following genotoxic stress and regulates the
expression of target genes involved in the DNA damage response (DDR). The discovery that …

Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …

p53, first described four decades ago, is now established as a master regulator of cellular
stress response, the “guardian of the genome”. p53 contributes to biological robustness by …

All living organisms have developed processes to sense and address environmental
changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour …

The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β
activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates …

Simple Summary TP53, the most frequently mutated gene in human cancers, has a key role
in the maintenance of the genetic stability and, thus, in preventing tumor development. The …

Dysfunctional p53 formation and activity can result from aberrant expression and subcellular
localization of distinct p53 isoforms or aggregates. Endometrial carcinoma (EC) is a cancer …

TP53 mutations are associated with tumour progression, resistance to therapy and poor
prognosis. However, in breast cancer, TP53′ s overall mutation frequency is lower than …

The p53 protein is a tumor suppressor and the most often mutated protein in human cancers.
Recent studies reported that p53 mutants, including two of the common cancer mutants …

As a member of the death-associated protein kinase family of serine/threonine kinases, the
STK17B has been associated with diverse diseases such as hepatocellular carcinoma …