The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

ABSTRACT Introduction Various pharmacogenomic (PGx) variants differ widely in different
ethnicities. and clinical outcomes associated with these variants may also be substantially …

Motivation Drug–drug interaction (DDI) prediction is a challenging problem in pharmacology
and clinical applications. With the increasing availability of large biomedical databases …

The use of small molecules became one key cornerstone of targeted anti-cancer therapy.
Among them, tyrosine kinase inhibitors (TKIs) are especially important, as they were the first …

The activity of cytochrome P450 enzymes is influenced by genetic and nongenetic factors;
hence, the metabolism of exogenous psychotropic medications and potentially some …

Background Adequate opioid prescribing is critical for therapeutic success of pain
management. Despite the widespread use of opioids, optimized opioid therapy remains …

Pharmacogenomics can identify polymorphisms in genes involved in drug pharmacokinetics
and pharmacodynamics determining differences in efficacy and safety and causing inter …

Vitamin D has received considerable optimistic attention as a potentially important factor in
many pathological states over the past few decades. However, the proportion of the active …

Peripheral vestibular disease can be treated with several approaches (eg, maneuvers,
surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is …

Purpose: This study was performed to investigate the effects of common polymorphisms in
CYP2D6 and CYP3A5 on the plasma concentrations and antihypertensive effects of …