" The story is told by THE inventor-pioneer-master in the field and is accompanied by
amazing illustrations...[it] will become an absolute reference and a best seller in chemistry!" …

Phage T4 has provided countless contributions to the paradigms of genetics and
biochemistry. Its complete genome sequence of 168,903 bp encodes about 300 gene …

Nature has evolved complex enzyme architectures that facilitate the synthesis and
manipulation of the biopolymers DNA and RNA, including enzymes capable of attaching to …

The past few decades have seen tremendous progress in the synthesis and operation of
molecular systems capable of controlled mechanical movement. Here, we review the use of …

Fluorescence resonance energy transfer (FRET) provides a unique means of measuring
interatomic distances in biological molecules in real time. Recent advances have been …

Bacteriophages (prokaryotic viruses) are favourite model systems to study DNA replication
in prokaryotes, and provide examples for every theoretically possible replication …

Sliding clamps are ring-shaped proteins that tether DNA polymerases to DNA, which
enables the rapid and processive synthesis of both leading and lagging strands at the …

The combination of biology and nanotechnology has led to a new generation of
nanodevices that make it possible to characterize the chemical, mechanical, and other …

Proceedings of the National Academy of Sciences Colloquium on the roles of homologous
recombination in DNA replication are summarized. Current findings in experimental systems …

Replisomes are the protein assemblies that replicate DNA. They function as molecular
motors to catalyze template-mediated polymerization of nucleotides, unwinding of DNA, the …