Bioconversion of renewable lignocellulosics to produce liquid fuels and chemicals is one of
the most effective ways to solve the problem of fossil resource shortage, energy security, and …

Our understanding of what determines ligand affinity of proteins is poor, even with high-
resolution structures available. Both the non-covalent ligand–protein interactions and the …

Objectives This study aimed to develop an efficient enzymatic strategy for the industrial
production of phenylpyruvate (PPA) from l-phenylpyruvic acid (l-Phe). Results l-amino acid …

Ancestral protein sequence reconstruction is a powerful technique for explicitly testing
hypotheses about the evolution of molecular function, allowing researchers to meticulously …

The ATP-binding cassette transporter GlnPQ is an essential uptake system that transports
glutamine, glutamic acid and asparagine in Gram-positive bacteria. It features two extra …

Allosteric regulation by ATP of peptide binding with a cAMP-dependent protein kinase
catalytic subunit was computationally modeled by combining conventional docking analysis …

GPCR immobilization is fundamental for many bioanalytical methods, which are crucial for
receptor-ligand interaction analysis and drug discovery. A desirable way to immobilize …