Protein conformational ensembles in function: roles and mechanisms
The sequence-structure-function paradigm has dominated twentieth century molecular
biology. The paradigm tacitly stipulated that for each sequence there exists a single, well …
biology. The paradigm tacitly stipulated that for each sequence there exists a single, well …
Recent applications of fluorescence correlation spectroscopy in live cells
AW Smith - Current Opinion in Chemical Biology, 2024 - Elsevier
As a time-domain analogue of fluorescence imaging, FCS offers valuable insights into
molecular dynamics, interactions, and concentrations within living cells. The primary insight …
molecular dynamics, interactions, and concentrations within living cells. The primary insight …
Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry
F Bock, X Dong, S Li, OM Viquez, E Sha… - Science …, 2024 - science.org
Prolonged obstruction of the ureter, which leads to injury of the kidney collecting ducts,
results in permanent structural damage, while early reversal allows for repair. Cell structure …
results in permanent structural damage, while early reversal allows for repair. Cell structure …
Whole-genome transcriptome and DNA methylation dynamics of pre-implantation embryos reveal progression of embryonic genome activation in buffaloes
P Fu, D Zhang, C Yang, X Yuan, X Luo… - Journal of Animal …, 2023 - Springer
Background During mammalian pre-implantation embryonic development (PED), the
process of maternal-to-zygote transition (MZT) is well orchestrated by epigenetic …
process of maternal-to-zygote transition (MZT) is well orchestrated by epigenetic …
[HTML][HTML] Propylparaben exposure impairs G2/M and metaphase-anaphase transition during mouse oocyte maturation
ZN Pan, LL Zhuang, HS Zhao, SY Yin, M Chu… - Ecotoxicology and …, 2024 - Elsevier
Propylparaben (PrPB) is a known endocrine disrupting chemicals that is widely applied as
preservative in pharmaceuticals, food and cosmetics. PrPB has been detected in human …
preservative in pharmaceuticals, food and cosmetics. PrPB has been detected in human …
CDK5–cyclin B1 regulates mitotic fidelity
CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to
drive mitotic progression. Here we demonstrate that CDK5 is active during mitosis and is …
drive mitotic progression. Here we demonstrate that CDK5 is active during mitosis and is …
2-Chloro-3-cyano-4-nitrobenzyl pyridinium bromide as a potent anti-lung cancer molecule prepared using a single-step solvent-free method
S Govindaraj, K Ganesan, P Elumalai, R Jeevitha… - RSC …, 2024 - pubs.rsc.org
Mono-/dimeric-substituted pyridinium and pyrazolium bromides were prepared under
conventional and solvent-free silica-supported domestic microwave conditions. The atom …
conventional and solvent-free silica-supported domestic microwave conditions. The atom …
Spatial control of the APC/C ensures the rapid degradation of cyclin B1
L Cirillo, R Young, S Veerapathiran, A Roberti… - The EMBO …, 2024 - embopress.org
The proper control of mitosis depends on the ubiquitin-mediated degradation of the right
mitotic regulator at the right time. This is effected by the Anaphase Promoting …
mitotic regulator at the right time. This is effected by the Anaphase Promoting …
Depletion of ELMOD3 inhibits the growth and migration of gastric cancer cells by disrupting the β‐catenin signaling and the F‐actin cytoskeleton
P Guo, C Xu, X Zhang, J Feng, Y Lou, S Ye… - The FASEB …, 2024 - Wiley Online Library
ELMOD3 (encoding ELMO domain containing 3) is a causative gene associated with human
autosomal dominant nonsyndromic and progressive hearing loss. However, the role of …
autosomal dominant nonsyndromic and progressive hearing loss. However, the role of …
[HTML][HTML] Regulatory role of the miR-142-3p/CDC25C axis in modulating autophagy in non-small cell lung cancer
J Meng, Z Song, S Cong, Q Sun, Q Ma… - Translational Lung …, 2024 - ncbi.nlm.nih.gov
Regulatory role of the miR-142-3p/CDC25C axis in modulating autophagy in non-small cell lung
cancer - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …
cancer - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …