Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

The prevalence of gastric cancer is associated with several factors including geographical
location, diet, and genetic background of the host. However, it is evident that infection with …

Cyclosporine and tacrolimus are immunosuppressive drugs largely used in renal
transplantation. They are characterized by a wide inter-individual variability in their …

Drug transporters are increasingly recognized as a key determinant of drug disposition and
response. It is now widely appreciated that expression of the ATP-dependent efflux …

Interethnic variability in pharmacokinetics can cause unexpected outcomes such as
therapeutic failure, adverse effects, and toxicity in subjects of different ethnic origin …

Drug resistance is a major obstacle to the successful treatment of cancer as tumor cells
either fail to reduce in size following chemotherapy or the cancer recurs after an initial …

Calcineurin inhibitors, tacrolimus (FK506) and cyclosporine (ciclosporin A), are the primary
immunosuppressive agents used on recipients of organ transplantations. The hepatic …

The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …

Multidrug resistant transporter MDR1WP-glycoprotein, the gene product of MDR1, is a
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette …

Objective Our objective was to determine the relationship between single nucleotide
polymorphisms (SNPs) in the multidrug resistance 1 (MDR‐1) gene and the cytochrome …