Extracellular matrix structure
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …
Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
[HTML][HTML] Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
RV Iozzo, L Schaefer - Matrix biology, 2015 - Elsevier
We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …
Insulin receptor isoforms in physiology and disease: an updated view
A Belfiore, R Malaguarnera, V Vella… - Endocrine …, 2017 - academic.oup.com
The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
Extracellular matrix, a hard player in angiogenesis
M Mongiat, E Andreuzzi, G Tarticchio… - International journal of …, 2016 - mdpi.com
The extracellular matrix (ECM) is a complex network of proteins, glycoproteins,
proteoglycans, and polysaccharides. Through multiple interactions with each other and the …
proteoglycans, and polysaccharides. Through multiple interactions with each other and the …
Decorin interacting network: a comprehensive analysis of decorin-binding partners and their versatile functions
Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …
The role of decorin in autoimmune and inflammatory diseases
Y Dong, J Zhong, L Dong - Journal of Immunology Research, 2022 - Wiley Online Library
Decorin is an extracellular matrix protein that belongs to the family of small leucine‐rich
proteoglycans. As a matrix protein, the first discovered role of decorin is participating in …
proteoglycans. As a matrix protein, the first discovered role of decorin is participating in …
Pivotal role for decorin in angiogenesis
H Järveläinen, A Sainio, TN Wight - Matrix Biology, 2015 - Elsevier
Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly
complex process. It is regulated in a finely-tuned manner by numerous molecules including …
complex process. It is regulated in a finely-tuned manner by numerous molecules including …
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine
Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …
Decorin as a multivalent therapeutic agent against cancer
Decorin is a prototypical small leucine-rich proteoglycan that epitomizes the multifunctional
nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine …
nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine …