Extracellular matrix structure

AD Theocharis, SS Skandalis, C Gialeli… - Advanced drug delivery …, 2016 - Elsevier
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics

NK Karamanos, Z Piperigkou, AD Theocharis… - Chemical …, 2018 - ACS Publications
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

[HTML][HTML] Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

RV Iozzo, L Schaefer - Matrix biology, 2015 - Elsevier
We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Insulin receptor isoforms in physiology and disease: an updated view

A Belfiore, R Malaguarnera, V Vella… - Endocrine …, 2017 - academic.oup.com
The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Extracellular matrix, a hard player in angiogenesis

M Mongiat, E Andreuzzi, G Tarticchio… - International journal of …, 2016 - mdpi.com
The extracellular matrix (ECM) is a complex network of proteins, glycoproteins,
proteoglycans, and polysaccharides. Through multiple interactions with each other and the …

Decorin interacting network: a comprehensive analysis of decorin-binding partners and their versatile functions

MA Gubbiotti, SD Vallet, S Ricard-Blum, RV Iozzo - Matrix Biology, 2016 - Elsevier
Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …

The role of decorin in autoimmune and inflammatory diseases

Y Dong, J Zhong, L Dong - Journal of Immunology Research, 2022 - Wiley Online Library
Decorin is an extracellular matrix protein that belongs to the family of small leucine‐rich
proteoglycans. As a matrix protein, the first discovered role of decorin is participating in …

Pivotal role for decorin in angiogenesis

H Järveläinen, A Sainio, TN Wight - Matrix Biology, 2015 - Elsevier
Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly
complex process. It is regulated in a finely-tuned manner by numerous molecules including …

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

AD Theocharis, SS Skandalis, T Neill… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …

Decorin as a multivalent therapeutic agent against cancer

T Neill, L Schaefer, RV Iozzo - Advanced drug delivery reviews, 2016 - Elsevier
Decorin is a prototypical small leucine-rich proteoglycan that epitomizes the multifunctional
nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine …