Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the
startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the …

The history of serotonin research is closely related to the study of hallucinogenic drugs that
function as agonists at serotonin-2A receptors. The fundamental idea that psychotic states …

Background: Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5-
HT) and dopamine receptors. Despite the therapeutic and scientific interest in LSD, specific …

Background After no research in humans for> 40 years, there is renewed interest in using
lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no …

Histone deacetylases (HDACs) compact chromatin structure and repress gene transcription.
In schizophrenia, clinical studies demonstrate that HDAC inhibitors are efficacious when …

Abstract The serotonin-2A receptor (5-HT 2A R) has been implicated in the pathogenesis of
schizophrenia and related inhibitory gating and behavioral inhibition deficits of …

The objective of this review is to identify a target or biomarker of altered neurochemical
sensitivity that is common to the many animal models of human psychoses associated with …

Behavioral phenotyping has been gaining prominence due to the increased use of
transgenic animal models of neurological disorders. Repeated testing in the same cohort of …

Cannabis contains over 70 unique compounds and its abuse is linked to an increased risk of
developing schizophrenia. The behavioural profiles of the psychotropic cannabis constituent …

Mutant mouse models related to schizophrenia have been based primarily on the
pathophysiology of schizophrenia, the known effects of antipsychotic drugs, and candidate …