Antagonic effect of ghrelin and LEAP-2 on hepatic stellate cell activation and liver fibrosis in obesity-associated nonalcoholic fatty liver disease
S Ezquerro, C Tuero, S Becerril… - European Journal of …, 2023 - academic.oup.com
Background Growing evidence suggests the key role of ghrelin in the onset and progression
of nonalcoholic fatty liver disease (NAFLD). The potential participation of ghrelin and the …
of nonalcoholic fatty liver disease (NAFLD). The potential participation of ghrelin and the …
Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent …
MF Andreoli, AS Fittipaldi, D Castrogiovanni… - European Journal of …, 2024 - Springer
Purpose The liver-expressed antimicrobial peptide 2 (LEAP2) is a newly recognized peptide
hormone that acts via the growth hormone secretagogue receptor (GHSR) blunting the …
hormone that acts via the growth hormone secretagogue receptor (GHSR) blunting the …
[HTML][HTML] Nutrient sensing: LEAP2 concentration in response to fasting, glucose, lactate, and β-hydroxybutyrate in healthy young males
MGB Pedersen, ES Lauritzen, MV Svart, J Støy… - The American Journal of …, 2023 - Elsevier
Background The appetite-suppressing potential of liver-expressed antimicrobial peptide 2
(LEAP2), and its antagonistic effects on the hunger-inducing hormone ghrelin have attracted …
(LEAP2), and its antagonistic effects on the hunger-inducing hormone ghrelin have attracted …
Postprandial increases in liver-gut hormone LEAP2 correlate with attenuated eating behavior in adults without obesity
R Bhargava, S Luur, M Rodriguez Flores… - Journal of the …, 2023 - academic.oup.com
Background The novel liver-gut hormone liver-expressed antimicrobial peptide-2 (LEAP2) is
a centrally acting inverse agonist, and competitive antagonist of orexigenic acyl ghrelin (AG) …
a centrally acting inverse agonist, and competitive antagonist of orexigenic acyl ghrelin (AG) …
[HTML][HTML] Decoding the influence of central LEAP2 on food intake and its effect on accumbal dopamine release
M Tufvesson-Alm, Q Zhang, C Aranäs… - Progress in …, 2024 - Elsevier
The gut-brain peptide ghrelin and its receptor are established as a regulator of hunger and
reward-processing. However, the recently recognized ghrelin receptor inverse agonist, liver …
reward-processing. However, the recently recognized ghrelin receptor inverse agonist, liver …
The dietary regulation of LEAP2 depends on meal composition in mice
AKJ Gradel, SK Holm, S Byberg… - The FASEB …, 2023 - Wiley Online Library
Ghrelin represents a key hormone regulating energy balance. Upon activation of the growth
hormone secretagogue receptor (GHSR), ghrelin increases blood glucose levels, food …
hormone secretagogue receptor (GHSR), ghrelin increases blood glucose levels, food …
[HTML][HTML] High-fat diet induces resistance to ghrelin and LEAP2 peptide analogs in mice
H Lucie, T Tureckiova, J Kuneš, B Železná… - Physiological …, 2023 - ncbi.nlm.nih.gov
Recent data suggest that the orexigenic peptide ghrelin and liver-expressed antimicrobial
peptide 2 (LEAP2) have opposing effects on food intake regulation. Although circulating …
peptide 2 (LEAP2) have opposing effects on food intake regulation. Although circulating …
[HTML][HTML] To eat or not to eat: A role for ghrelin and LEAP2 in eating disorders?
V Tolle, CT du Montcel, J Mattioni, E Schéle… - Neuroscience …, 2024 - Elsevier
Ghrelin is an orexigenic hormone that orchestrates many diverse behaviours of relevance
for feeding control. It appears to operate as a hunger hormone, organizing food intake into …
for feeding control. It appears to operate as a hunger hormone, organizing food intake into …
Plasma LEAP-2 following a low-calorie diet with or without interval exercise in women with obesity
TJ Ragland, SK Malin - Nutrients, 2023 - mdpi.com
Liver-expressed antimicrobial peptide-2 (LEAP-2) is associated with caloric intake and
glucose metabolism. Purpose: Assess if a low-calorie diet with interval exercise (LCD+ INT) …
glucose metabolism. Purpose: Assess if a low-calorie diet with interval exercise (LCD+ INT) …
[HTML][HTML] Intestinal expression profiles and hepatic expression of LEAP2, ghrelin and their common receptor, GHSR, in humans
Liver-expressed antimicrobial peptide 2 (LEAP2) and ghrelin have reciprocal effects on their
common receptor, the growth hormone secretagogue receptor (GHSR). Ghrelin is …
common receptor, the growth hormone secretagogue receptor (GHSR). Ghrelin is …