Infections lacking precise diagnosis are often caused by a rare or uncharacterized
pathogen, a combination of pathogens, or a known pathogen carrying undocumented or …

Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic
heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is …

Metagenomic next-generation sequencing (mNGS) has shown promise in the diagnosis of
infectious diseases in adults, while its efficacy in pediatric infections remains uncertain. We …

Bacteriological diagnosis is traditionally based on culture. However, this method may be
limited by the difficulty of cultivating certain species or by prior exposure to antibiotics, which …

Recent advancements in sequencing technology and data analytics have led to a
transformative era in pathogen detection and typing. These developments not only expedite …

Background Pneumoconiosis patients have a high prevalence of pulmonary infections,
which can complicate diagnosis and treatment. And there is no comprehensive study of the …

This article advocates for mobilizing pathogen genomic surveillance to contain and mitigate
health threats from infectious diseases and antimicrobial resistance (AMR), building upon …

Shotgun-metagenomics may give valuable clinical information beyond the detection of
potential pathogen (s). Identification of antimicrobial resistance (AMR), virulence genes and …

The increasing prevalence of gut colonization with CTX-M extended-spectrum β-lactamase-
and/or DHA plasmid-mediated AmpC-producing Escherichia coli is a concern. Here, we …

Before implementing metagenomic next-generation sequencing (mNGS) in the routine
diagnostic laboratory, several challenges need to be resolved. To address strengths and …