Cell membranes with their selective permeability play important functions in the tight control
of molecular exchanges between the cytosol and the extracellular environment as the …

Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

Basic research in genetics, biochemistry and cell biology has identified the executive
enzymes and protein kinase activities that regulate the cell division cycle of all eukaryotic …

Diffuse gliomas are among the most common adult central nervous system tumors with an
annual incidence of more than 16,000 cases in the United States. Until very recently, the …

Thousands of naturally occurring peptides differing in their origin, abundance and possible
functions have been identified in the tissue and biological fluids of vertebrates, insects, fungi …

Intracellular peptides are produced by proteasomes following degradation of nuclear,
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …

The proteasome cleaves intracellular proteins into peptides. Earlier studies found that
treatment of human embryonic kidney 293T (HEK293T) cells with epoxomicin (an …

Sea anemones are sessile invertebrates of the phylum Cnidaria and their survival and
evolutive success are highly related to the ability to produce and quickly inoculate venom …

Hemopressin (PVNFKFLSH in rats, and PVNFKLLSH in humans and mice), a fragment
derived from the α-chain of hemoglobin, was the first peptide described to have type 1 …

Highlights•Proteomics is a valuable tool for biomarker and novel therapeutic target
discovery.•Omics tools are key methodologies designed to target specific biological …