Telomeric DNA challenges the replisome and requires TRF1 for efficient duplication. TRF1
recruits the BLM helicase, but BLM loss does not explain the extensive telomere fragility …

The helicase XPD is known as a key subunit of the DNA repair/transcription factor TFIIH.
However, here, we report that XPD, independently to other TFIIH subunits, can localize with …

Genomes are organised into DNA loops by the Structural Maintenance of Chromosomes
(SMC) proteins. SMCs establish functional chromosomal sub-domains for DNA repair, gene …

Condensin shapes mitotic chromosomes by folding chromatin into loops, but whether it does
so by DNA-loop extrusion remains speculative. Although loop-extruding cohesin is stalled …

Mitotic chromosome assembly is an essential preparatory step for accurate transmission of
the genome during cell division. During the past decades, biochemical approaches have …

Aneuploidy is a pervasive feature of cancer cells that results from chromosome
missegregation. Several transcription factors have been associated with aneuploidy; …

Over the last several years enormous progress has been made in identifying the molecular
machines, including condensins and topoisomerases that fold mitotic chromosomes. The …

Histone modifications influence the recruitment of reader proteins to chromosomes to
regulate events including transcription and cell division. The idea of a histone code, where …

Condensin complexes promote the drastic spatial rearrangement of the genome upon
mitotic entry. Condensin II initiates chromosome condensation in early mitosis. To prevent …

Faithful chromosome segregation requires packaging of the genome on both global and
local scales. Condensin plays a crucial role at pericentromeres to resist spindle forces and …