Approximately half of all patients with heart failure (HF) have a preserved ejection fraction,
and the prevalence is growing rapidly given the aging population in many countries and the …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Diabetes mellitus is one of the prime risk factors for cardiovascular complications and is
linked with high morbidity and mortality. Diabetic cardiomyopathy (DCM) often manifests as …

Flavonoids are found in the roots, stems, leaves, and fruits of many plant taxa. They are
related to plant growth and development, pigment formation, and protection against …

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome associated
with increased myocardial stiffness and cardiac filling abnormalities. Prior studies implicated …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …

Abstract Background Tyrosine kinase inhibitors (TKIs) are anti-cancer therapeutics often
prescribed for long-term treatment. Many of these treatments cause cardiotoxicity with limited …

Heart failure with preserved ejection fraction (HFpEF) is a major, worldwide health-care
problem. Few therapies for HFpEF exist because the pathophysiology of this condition is …

Heart failure (HF) is characterized by a progressive decline in cardiac function and
represents one of the largest health burdens worldwide. Clinically, 2 major types of HF are …